Technology development
EubioQuercetin
EubioFlavonoid® delivery technology allows EubioQuercetin to have excellent water solubility. It leads to significant enhancement of oral absorption of the active flavonoids ( Highly absorbable Qurecetin ) based on rutin*. EubioQuercetin is produced only with safe ingredients and additives. This product is very different from artificial flavonoids that have been enzymatically or chemically modified.
*Rutin is quercetin-3-O-rutinoside.
Water Solubility of EubioQuercetin
The bar chart shown in Fig 1 allows to compare the water-solubility difference between EubioQuercetin and rutin.
Since EubioQuercetin is at least 240,000 times more water soluble compared to quercetin, it is expected to have wide application, including in cosmetic, beverage, food, supplement, and pharmaceutical industries.
Fig 1 Water-solubility of EubioQuercetin
Applications of EubioQuercetin
As a natural food additive
-
Preservative
Food coloring agent
Food flavoring agent
Anti-color fading agent
Shelf life-prolonging
As a natural health promoting material proposed
by various experimental models*1 and human clinical trial*2
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Sun screen effects
Antidiabetic effects
Antihypercholesterolemic effects
Anti platelet aggregation effects
Anti-thrombotic effects
Anti-ulcer effects
Hepatoprotective effects
Cardioprotective effects
Neuroprotective effects
Anti-Allergic effects (hay fever)
Dental hygiene
Anti-skin aging*2
*1 A. Ganeshpurkar etal., the pharmacological potential of Rutin, Saudi Pharmaceutical Journal (2017) 25, 149-164
*2 Choi SJ etal., Biological effects of rutin on skin aging, Int J Mol Med., (2016) 38, 357-358
Safety of EubioQuercetin
- As Rutin
-
Acute toxicity : LD504000mg / kg (IV injection for mice)
Repeated dose toxicity : Diets containing 0.6g/Kg/day for adult rat for 400 days. No evidence of histological injury, no organ weight change, no estrous cycle change compared to normal rats.
Mutagenicity : DNA repair test using bacteria, chromosome aberration test using cultured mammalian cells, micronucleus test using mice．The results of are all negative.
*J Am Pharm Assoc. 1950 Oct; 39(10):556-9.
- As EubioQuercetin
-
Acute toxicity : LD50 > 8700 mg/kg（Oral administration for rats)
Subacute toxicity : NOAEL 1000mg/kg/day (90day repeated dose toxicity test, oral, rat)
Mutagenicity (in vivo) : Micronucleus negative (rat)
Regulatory Status
All ingredients in EubioQuercetin are GRAS listed in USA and food additives in EU.
Patent Status
COMPOSTION OF O-GLYCOSYL FLAVONOIDS
- PCT/JP2019/17262
- US PATENT NO. 11266671
- JP PATENT NO. 6764206
RUTIN COMPOSITIONS
- US PATENT NO.10918654
- JP PATENT NO. 6763590
Specification of EubioQuercetin
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| Tests | Specifications | |
|---|---|---|
| Description | Appearance | Light yellow to orange powder |
| Clarity | Clear (1% in water) | |
| Purity | Heavy metals | Not more than 20 μg/g |
| Cadmium | Not more than 1 μg/g | |
| Lead | Not more than 0.5μg/g | |
| Arsenic | Not more than 4 μg/g | |
| Mercury | Not more than 9 μg/g | |
| Loss on drying | Not more than 8 % | |
| Assay | Quercetin-3-rutinoside(Rutin) | Not less than 50 % |
| L-Arginine | Not less than 25 % | |
| Microbiological test | Bacteria | Not more than 3000cfu/g |
| Molds and Yeasts | Not more than 100cfu/g | |
| Coliforms | Negative | |
| Recommended Shelf Life | 3years | |
EubioQuercetin Pamphlet
EubioQuercetin Special Site